GLENDALE, Ariz. — Peyton Manning and Kurt Warner have thrown for miles and miles in their NFL careers, yet their paths crossed for only the second time on Sunday night.
Manning threw four touchdown passes, three in the second quarter, to power the Indianapolis Colts past Warner and the turnover-plagued Arizona Cardinals 31-10.
The Colts’ quarterback completed 24-of-35 for 379 yards with one interception.
Warner, under severe pressure much of the night, was 30-of-52 for 332 yards and one score but was picked off twice.
Indianapolis safety Antoine Bethea recovered a fumble at the 5-yard line to stop one Arizona drive and intercepted a deflected pass in the end zone to thwart another.
Manning had four TD passes in a game for the 18th time, moving him ahead of Johnny Unitas into third on the NFL career list, behind Dan Marino’s 21 and Brett Favre’s 20.
Wayne made a one-handed grab of Manning’s pass at the pylon on a 20-yard play that made it 7-3 with 9:04 left in the half, giving the Colts the lead for good.
“Can’t draw that up,” Manning said.
Arizona, 8-2 at home last season, fell to 0-2 there this season, with echoes of boos through what was left of the crowd as Warner was sacked for a 28-yard loss on fourth down with about 6 1/2 minutes to play.
