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LUCASVILLE, Ohio — An Ohio killer was put to death in 10 minutes Tuesday in the first U.S. execution to use a single- drug injection instead of the standard three-chemical combination that has come under legal attack because it can cause excruciating pain.

Kenneth Biros, 51, was pronounced dead shortly after one dose of sodium thiopental began flowing into his veins at the Southern Ohio Correctional Facility. The U.S. Supreme Court had rejected his final appeal two hours earlier.