Week 10 is filled with familiar matchups and division rivalries. Arizona goes to Seattle with a chance to all but dethrone a team that has dominated the NFC West the last two seasons. Also, New England seeks to finally deny its kryptonite. The Patriots haven’t beaten the New York Giants since December 2007, including two Super Bowl losses to Eli Manning.
Detroit at Green Bay, 11 a.m., KDVR-31. The Packers are reeling after road losses to the NFL’s two best defenses. They’ll get to regroup and rebound at home against the 1-7 Lions, who average an NFL-low 69.6 rushing yards per game.
Dallas at Tampa Bay, 11 a.m. The Cowboys are the losers of six straight and ready to explode every day. They can’t afford a road loss to Jameis Winston’s squad — or they can pack up their season in mid-November.
Miami at Philadelphia, 11 a.m. Sam Bradford is coming off his best performance of the season in an overtime win over Dallas. Consistency is the key for Bradford and the Eagles, who are winners of three of their last four.
Carolina at Tennessee, 11 a.m. The Panthers have established themselves as the class of the NFC behind a dominant defense and No. 1-ranked running attack. The Titans are a big win away from propelling themselves back into the AFC South race.
Chicago at St. Louis, 11 a.m. Todd Gurley has the Rams dreaming of higher pastures, but it’s up to quarterback Nick Foles to get them over the stump. It starts with winning home games against bad teams.
New Orleans at Washington, 11 a.m. The Saints overcame their porous defense for three straight wins before succumbing to the Titans last week. Does Washington have the firepower to keep up with Drew Brees?
Cleveland at Pittsburgh, 11 a.m., KCNC-4. Without Ben Roethlisberger and Le’Veon Bell, the Steelers have still held strong with Landry Jones and DeAngelo Williams handling the load. They’ll have to do it again Sunday against a division opponent.
Jacksonville at Baltimore, 11 a.m. Two 2-6 teams not ready to give up their grim playoff hopes. The Ravens are ravaged by injuries; the Jaguars overwhelmed with youth and inconsistency. The loser receives a nail in the coffin of its postseason dreams.
Minnesota at Oakland, 2:05 p.m. Derek Carr is growing closer and closer to being a top-10 QB. His 19-4, touchdown-to-interception ratio has brought the Raiders into the AFC playoff conversation.
New England at New York Giants, 2:25 p.m. The Giants are the only team the Patriots haven’t beaten since 2007. Eli Manning versus Tom Brady means a shootout could be in store. The quarterbacks are the same, but the Giants lack that once-feared pass rush.
Houston at Cincinnati, 6:30 p.m. Monday, ESPN. Texans wideout DeAndre Hopkins is third in the NFL in receiving with 870 yards. Bengals receiver A.J. Green is not too far behind him. Who will have the better game?
Game of the week
Arizona at Seattle, 6:30, KUSA-9.
For the majority of the decade, Arizona has been the third wheel of a largely two-way battle between Seattle and San Francisco for the NFC West crown. With Carson Palmer healthy and a two-game lead over the Seahawks, it’s their title to lose. But, they’ll have to beat the champ to be the champ.
Cameron Wolfe: 303-954-1891, cwolfe@denverpost.com or @CameronWolfe
