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ISLAMABAD — A U.S. missile strike Friday targeted a Taliban commander blamed for masterminding ambushes on American troops in Afghanistan, the latest assault by unmanned aircraft in northwestern Pakistan, intelligence officials said.

It was unclear whether Siraj Haqqani, who also has close ties to al-Qaeda, was among the 12 people killed in the house near the Afghan border, officials said, adding that three women were among the dead. Haqqani is known to have visited the house.

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