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Japanese drugmaker Astellas Pharma said Monday it will take a $3.5 billion takeover offer for OSI Pharmaceuticals directly to shareholders after being rebuffed several times by executives of the U.S. biotechnology company.

Astellas said it will start today an offer to pay $52 per share in cash for all outstanding common shares of the OSI Pharmaceuticals stock — a premium of more than 40 percent over Friday’s close.

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