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MIR ALI, Pakistan — At least one suspected U.S. drone fired on a house in Pakistan’s volatile tribal region Sunday, killing 20 people in the 11th such attack since militants in the area orchestrated a deadly suicide bombing against the CIA in Afghanistan, intelligence officials said.

Four missiles slammed into the house in the Shaktoi area of South Waziristan. The house was being used by Usman Jan, the head of the al-Qaeda-linked Islamic Movement of Uzbekistan, intelligence officials said. Five Uzbeks were killed in the strike, but it was unclear whether Jan was among them.

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