WASHINGTON — The virus that causes AIDS can hide in the bone marrow, avoiding drugs and later awakening to cause illness, according to new research that could point the way toward better treatments for the disease.
Finding that hide-out is a first step, but much research lies ahead. Dr. Kathleen Collins of the University of Michigan and her colleagues report in this week’s edition of the journal Nature Medicine that the HIV virus can infect long-lived bone marrow cells that eventually convert into blood cells.
The virus is dormant in the bone marrow cells, she said, but when those progenitor cells develop into blood cells, it can be reactivated and cause renewed infection.
“If we’re ever going to be able to find a way to get rid of the cells, the first step is to understand” where a latent infection can continue, Collins said.
In recent years, drugs have reduced AIDS deaths sharply, but patients need to keep taking the medicines for life or the infection comes back, she said. That is an indication that although the drugs battle the active virus, some of the disease remains hidden away to flare up once the therapy is stopped.
Finding these sources of infection is important because eliminating them would allow AIDS patients to stop taking drugs after their infection was over. That is critical in countries where the treatment is hard to afford and deliver.
