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KARACHI, Pakistan — Gunmen opened fire on two buses and waged street battles in Pakistan’s largest city Thursday, killing at least 22 people as part of a spate of violence that has resulted in 49 deaths in three days, officials said.

It was some of the worst strife so far this year in Karachi, a city of 18 million that has long been a hotbed of crime and clashes — much of it linked to ethnic, sectarian and political divisions. Police had no immediate comment on the possible motives for the latest killings.

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