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Washington – Scientists have found the first real evidence that restricting air travel can delay flu’s spread – a finding that could influence government plans for battling the next influenza pandemic.

Air travel has long been suspected of playing a role in flu’s gradual spread around the globe each year. But Monday, Boston researchers said they’ve finally documented it: The drop in air travel after the Sept. 11, 2001, terrorist attacks seemed to delay that winter’s flu season by about two weeks.

“This is the first time that a study’s been able to show a direct link between the numbers of people traveling and the rate of spread of a virus,” said John Brownstein, an epidemiologist at Children’s Hospital of Boston, who led the new research.

“These data show such a striking effect,” added Dr. Kenneth Mandl, his co-author and a pediatric emergency physician at Children’s.

Other scientists stress that the study doesn’t prove restricting air travel really helps in the long run – there was no drop in the number of deaths, just a delay. So if a pandemic were to strike, the question is whether a mere two-week delay would outweigh the economic chaos of severe travel restrictions.

“You wouldn’t want to have people look at this and say, ‘Ah, this is overwhelming evidence that if the pandemic occurs, we should shut down air travel,”‘ cautioned Dr. Anthony Fauci of the National Institutes of Health, the government’s chief influenza specialist. “What does it buy you? That’s the real critical issue.”

Added Dr. William Schaffner of Vanderbilt University, who advises the government on flu issues: “We’re all sure that airlines play a role. … Leaping from this sort of analysis to interdiction of air travel I think is provocative, and we have to be very careful about that.”

People easily spread the flu through coughs, sneezes and germy hands. But scientists don’t understand how a community outbreak ripples outward until each winter’s flu strain spreads across countries. Plus, every few decades a new and virulent flu strain causes a worldwide epidemic; better understanding of those geographic patterns might help stem the next such pandemic.

Previous studies suggest that young children who bring the flu home to older relatives spark community outbreaks, which spread between U.S. cities and states when the sick go to work instead of recuperating at home.

Brownstein and Mandl compared their flu data to Transportation Department monthly air-travel estimates.

Brownstein said the findings, reported Monday in the online science journal PLoS Medicine, suggest that if a flu pandemic began, air-travel restrictions might buy a little time for health officials to take such steps as rounding up medications.

But “we’re not saying we could prevent the pandemic just by travel restrictions,” he stressed.

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