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TOPEKA, Kan. — The Department of Homeland Security has approved a site at Kansas State University for a $450 million lab to study livestock diseases and some of the world’s most dangerous biological threats. The agency released its final record of the approval Monday, confirming a decision announced in December to build the National Bio and Agro-Defense Facility at the Manhattan, Kan., campus to replace an aging lab at Plum Island, N.Y.

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