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HOUSTON — More than 2,200 people have been arrested during a 22-month investigation aimed at thwarting Mexican drug-cartel efforts to distribute narcotics across the U.S. and funnel guns and money south of the border, federal authorities said Thursday.

The probe, called Project Deliverance, focused on shutting down many of the cartels’ U.S.-based cells that smuggle drugs — including cocaine, heroin and marijuana — across the U.S.-Mexico border. More than 400 arrests were made Wednesday in 16 states, including Texas, California and Virginia.

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